Collaborative canine genomics: developing the next generation of genetic selection tools in working dogs – Presented by Frances Chen

Many canine cancers share genetic and environmental risk factors with human cancers, while their shorter lifespans enable longitudinal studies linking risk factors with cancer outcomes. This positions dogs as invaluable models for comparative and translational cancer research. DNA sequencing has been a transformative approach in cancer research, offering an opportunity to identify genetic variants associated with risk and target pathways for new therapies. Beyond research discovery, genomic data unlocks the potential for genomic selection as an approach to reduce heritable cancer risk in dogs. While genomic selection using genomic estimated breeding values (GEBVs) has been a proven, powerful approach in livestock, its potential has yet to be explored in dogs.

Leveraging DNA sequence data and longitudinal cancer outcomes from the Golden Retriever Lifetime Study and the International Working Dog Registry (IWDR), we have investigated inherited risk for canine hemangiosarcoma and provided initial evaluation of the feasibility of genomic selection in at-risk Golden Retrievers. In collaboration with IWDR, we are integrating estimated breeding values (EBVs) for hemangiosarcoma into working dog breeding programs to reduce disease incidence over time.

To accelerate the collection of genomic data needed for GEBVs, we have partnered with Gencove to offer a targeted capture panel for working dog populations. This tool offers high-accuracy genotyping for key trait-associated loci while incorporating whole-genome sequencing. It allows breeding programs to integrate collection of genomic data into their workflows for routine genetic testing, thereby laying the foundation for genomic selection tailored to their goals.

By aligning genomic discovery with practical selection strategies, this project aims to establish proof of concept that genomic EBVs can facilitate genetic selection against canine hemangiosarcoma while deepening our understanding of cancer genetics in both dogs and humans. Our collaboration with IWDR enables direct engagement with working dog organizations, laying the groundwork for integrating genomic tools into breeding programs to enhance the health and welfare of working dogs while driving discovery in cancer research for their human companions.

Coming soon.